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Researchers from the University of Veterinary Medicine Vienna conducted a retrospective study to evaluate the presence and correlation of equine parvohepatitis virus EqPV-H in the livers of horses and donkeys with histopathological abnormalities other than Tiller's disease. The researchers hope to confirm whether the newly discovered EqPV-H will cause other liver diseases through this study, and further analyze the infection pattern of the EqPV-H virus through the infection situation of EqPV-H.

Mitochondrial diseases are a class of genetic diseases caused by mutations in the mitochondrial genome (mtDNA), which are transmitted only through the female germ line. Usually, more than 60% of the mitochondrial DNA in a cell mutates to cause disease, and the more mitochondrial DNA mutations a person has, the more severe the disease. Mitochondrial diseases are currently incurable.

The Pasteur Institute in France published a high-scoring article (NATURE IMMUNOLOGY, IF: 25.6), using the naica® droplet chip digital PCR system from Stilla Technologies and the Apexbio coronavirus digital PCR detection kit to quantify the coronavirus load in plasma.

Vibrio cholerae is the pathogen of human cholera, which is an ancient and widespread severe infectious disease. It has caused many pandemics in the world, mainly manifested by severe vomiting, diarrhea, dehydration, and a high mortality rate. It is an international quarantine infectious disease. Understanding the replication principle of Vibrio cholerae can help people explore its infection mechanism more systematically.

The epidermal barrier is restored by activation, proliferation, and differentiation of keratinocyte stem cells, but this repair process is hampered after injury and aging through unclear mechanisms. The authors previously discovered genetic signatures of epidermal metabolic dysfunction in aged mice, but the precise regulatory mechanisms of epidermal repair and age-related growth defects have not been established. Therefore, the authors used an aging mouse model and mice with conditional epidermal deletion of the metabolic regulator peroxisome proliferator-activated receptor γ-coactivator-1α (Pgc-1α) to explore the cellular pathways that control skin repair after injury and stress.

Obesity refers to the accumulation of fat layers. Losing weight is not only for beauty, but also for health. Obesity has been proven to increase the risk of various diseases, such as cardiovascular disease, cancer, fatty liver, etc. However, for most people, controlling weight is very difficult.

Malaria is caused by the single celled protozoan parasite of the Plasmodium genus, which infects 200 million people and causes over 400000 deaths annually in humans. The eukaryotic cell cycle is usually divided into different stages, with cytoplasmic division occurring immediately after nuclear division. In order to ensure the correct progress of cell division, each stage of cell division is coordinated and controlled through feedback from checkpoints. But malaria parasites are different. In the asexual replication cycle of malignant malaria parasites, they undergo multiple rounds of asynchronous mitosis, accompanied by the separation of uncondensed chromosomes, followed by nuclear fission with a complete nuclear envelope. Then, the multinucleated cells undergo a round of cytoplasmic division, producing dozens of daughter cells called merozoites.

This article was jointly published in the Marine Pollution Bulletin in early 2020 by the Key Laboratory of Marine Environment and Ecology Education of the Institute of Advanced Oceanography at Ocean University of China, the China Marine Ecology and Environmental Science Laboratory, the Qingdao National Marine Science and Technology Laboratory, the China Institute of Environmental Processes and Pollution Control, and the School of Environment and Civil Engineering at Jiangnan University.

Ovarian cancer is a gynecological malignancy with a high mortality rate, and adjuvant treatments such as radiotherapy and chemotherapy inevitably lead to side effects and drug resistance. In recent years, traditional Chinese medicine has been widely studied for its safety, efficacy, and unique pharmacological effects. Polyphyllin VII is extracted from the Liliaceae plant, Polygonatum sibiricum, and has pharmacological effects such as anti-inflammatory, hemostatic, analgesic, and minimal side effects. It has significant anti-cancer activity against ovarian cancer, prostate cancer, gastric cancer, nasopharyngeal cancer, and colon cancer. Research has shown that saponins VII from Polygonatum sibiricum can induce mitochondrial pathway apoptosis by increasing mitochondrial fission, but the specific mechanism is still unclear.