Colorectal Cancer Methylation Detection Kit

This NMPA-approved (Reg. No. 20263400228), non-invasive screening kit utilizes a synergistic 4-gene methylation panel and the proprietary Methylcaller algorithm to deliver high-sensitivity detection of colorectal cancer and precancerous lesions from a simple stool sample, offering a precise and painless triage solution for early intervention.

Overview

Ordering Information

Resources

Key Advantages and Benefits

Multi-Target Synergy (4-Gene Panel): Combines four specific biomarkers—SDC2, NDRG4, WIF1, and TFPI2—to significantly reduce the risk of missing early-stage lesions compared to single-gene tests.

Proprietary Intelligence: Powered by the patented Methylcaller algorithm and ColoCaller scoring model (based on SVM and Lasso regression), improving AUC by 10% on average over single-gene methods.

Superior Clinical Performance: Demonstrated a sensitivity of 92.79% and a specificity of 94.21% in a clinical cohort of 1,428 samples, with an overall consistency of 93.77%

Non-Invasive & Convenient: Requires only a 3g stool sample. It eliminates the need for bowel preparation or dietary restrictions, providing a painless alternative to traditional colonoscopy.

High Sensitivity for Early Detection: Specifically designed to detect early adenomas and early-stage colorectal cancer, capturing the "Golden Window" for treatment.

Comparison of Early Screening Methods

Cross-Manufacturer Performance Comparison

Application Scenarios

Routine Screening (Population 40+): Ideal for individuals aged 40 and above as part of annual health check-ups.

High-Risk Groups: Individuals with a family history of CRC, a history of malignant tumors, or chronic conditions like diabetes.

Symptomatic Individuals: Those experiencing long-term digestive discomfort, such as persistent diarrhea, constipation, or inflammatory bowel disease (IBD).

Low Compliance Patients: A secondary screening option for those who are reluctant to undergo invasive colonoscopies.

Post-Operative Monitoring: Used for regular recurrence monitoring in patients who have undergone CRC surgery to detect early signs of relapse.

Workflow

Colorectal Cancer Methylation Detection Kit

Ordering Information

Catalog No.	Product Name	Specification	Description
H150006045	Human SDC2/NDRG4/WIF1/TFPI2 Gene Methylation Detection Kit (Fluorescence PCR Method)	45 Tests/Kit	NMPA-approved quantitative analysis of the methylation levels of four core tumor suppressor genes—namely, SDC2, NDRG4, WIF1, and TFPI2—significantly enhances the ability to detect early colorectal cancer and precancerous lesions, such as advanced adenomas.
H160007	Stool Collection Device	1 Test/Kit	Used for the collection, transport, and storage of stool specimens.
H160002	Stool DNA Extraction Kit (Magnetic Bead Method)	25 Tests/Kit	Utilizing a magnetic bead-based extraction method for the isolation, enrichment, and purification of fecal DNA. The resulting DNA products are suitable for clinical diagnostic applications.
H160008	Stool DNA Extraction Kit (Spin Column Method)	25 Tests/Kit	Utilizing a spin column-based method for the extraction, enrichment, and purification of fecal DNA. The resulting DNA products are suitable for clinical diagnostic applications.
H160010	DNA Methylation Kit	200 Tests/Kit	Bisulfite conversion, extraction, enrichment, and purification of nucleic acids. The resulting products are utilized for clinical genetic testing.

We have a variety of reference materials available, including color pages, technical guides, professional literature and operation videos. If you need to consult or obtain relevant materials, please fill in the information below to contact us.